Mathare and Kimanzi have struggled for form all season.
Spurs went unbeaten throughout their final league campaign at White Hart Lane.
Vihiga will paly Leopards while Kariobangi Sharks take on Sony Sugar in the semi-finals.
Manoah was sent off for continuously questioning the match referee's decisions.
Barca host Real Betis at the club's 99,000 capacity Camp Nou.