Barcelona coach Ernesto Valverde has included Sergi Roberto in his starting line-up in midfield for Tuesday's Champions League last 16, first leg against Lyon as Philippe Coutinho is left on the bench.
With Arthur on the sidelines, Valverde could have selected Coutinho alongside Sergio Busquets and Ivan Rakitic in his three-man midfield, but the Brazilian starts the game on the bench at the Groupama Stadium.
Arturo Vidal is also a substitute, as Roberto - more often used as a right-back - features in a Barcelona team showing four changes following their weekend win against Valladolid in La Liga.
Rakitic, Luis Suarez, Clement Lenglet and Nelson Semedo all return, as Barcelona chase a first away win in the Champions League knockout phase in three years.
The fit-again Samuel Umtiti is on the bench against his old side.
For Lyon, the absence of suspended captain Nabil Fekir has opened up the door for Martin Terrier to start on the left wing, with Memphis Depay expected to play in a central role. It is just a second Champions League start for the 21-year-old Terrier.
Jason Denayer is passed fit to start in defence in Lyon's first appearance in the knockout stage since the 2011/12 season.
Starting line-ups for the Champions League last 16, first leg between Lyon and Barcelona at the Groupama Stadium on Tuesday (kick-off 2000 GMT):
Anthony Lopes; Leo Dubois, Marcelo (capt), Jason Denayer, Ferland Mendy; Tanguy Ndombele, Houssem Aouar; Bertrand Traore, Memphis Depay, Martin Terrier; Moussa Dembele
Coach: Bruno Genesio (FRA)
Marc-Andre ter Stegen; Nelson Semedo, Gerard Pique, Clement Lenglet, Jordi Alba; Sergi Roberto, Sergio Busquets, Ivan Rakitic; Lionel Messi (capt), Luis Suarez, Ousmane Dembele
Coach: Ernesto Valverde (ESP)
Referee: Cuneyt Cakir (TUR)